Registration Dossier
Registration Dossier
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EC number: 259-915-0 | CAS number: 55947-46-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from QSAR prediction
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Determination of skin sensitization for Methallyl sulfonate
- Author:
- IUCLI database
- Year:
- 2 000
- Bibliographic source:
- EUROPEAN COMMISSION European Chemicals Bureau 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Skin sensitization study of Sodium vinylsulfonate was conducted in guinea pigs to determine its sensitization efficacy.
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Methallyl sulfonate
- IUPAC Name:
- Methallyl sulfonate
- Reference substance name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- EC Number:
- 216-341-5
- EC Name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- Cas Number:
- 1561-92-8
- IUPAC Name:
- sodium 2-methylprop-2-ene-1-sulfonate
- Reference substance name:
- 216–341–5
- IUPAC Name:
- 216–341–5
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (as cited in study report): sodium 2–methylprop–2–ene–1–sulphonate
- Molecular formula: C4H8O3S.Na
- Molecular weight: 158.152 g/mol
- Substance type: Organic
- Physical state: solid
Constituent 1
Constituent 2
Constituent 3
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: No data available
- Vehicle:
- no data
- Concentration / amount:
- No data available
Challengeopen allclose all
- Route:
- other: No data available
- Vehicle:
- no data
- Concentration / amount:
- No data available
- No. of animals per dose:
- 20
- Details on study design:
- No data available
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: No data available
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- Non Sensitizer
- Remarks on result:
- other: Reading: other: No data available. Group: test group. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: Non Sensitizer.
Any other information on results incl. tables
Not Specified
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material Methallyl sulfonate (CAS No:- 1561-92-8) was observed to be non sensitizing to guinea pigs .
- Executive summary:
The skin sensitization study ofMethallyl sulfonate(CAS No:-1561-92-8)was performed in 20 guinea pigs to observed its sensitizing potential according to guinea pig maximization test.The guinea pigs did not produce any sensitization potential .ThusMethallyl sulfonate(CAS No:-1561-92-8) was found to be non sensitizing to the guinea pigs.
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