Registration Dossier
Registration Dossier
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EC number: 259-915-0 | CAS number: 55947-46-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for the CAS 1561-92-8
- Author:
- EUROPEAN COMMISSION European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- EUROPEAN COMMISSION European Chemicals Bureau, 2000.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to USA Interagency Regulatory Liaison Group Testing Standards and Guidelines Work Group
- Principles of method if other than guideline:
- According to USA Interagency Regulatory Liaison Group Testing Standards and Guidelines Work Group
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- EC Number:
- 216-341-5
- EC Name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- Cas Number:
- 1561-92-8
- IUPAC Name:
- sodium 2-methylprop-2-ene-1-sulfonate
- Reference substance name:
- sodium methallyl sulphonate
- IUPAC Name:
- sodium methallyl sulphonate
- Test material form:
- other: solid
- Details on test material:
- common name: sodium methallyl sulphonate
substance type: organic
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 72 hours
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0.33
- Max. score:
- 110
- Remarks on result:
- other: Irritation index: 0.33/110
- Irritant / corrosive response data:
- Irritation index: 0.33/110
or as the mean of 6 animals at 24, 48 and 72 hours: cornea: 0.06
iris: 0.0, conjunctiva: redness: 0.5, chemosis: 0.3
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an eye irritation study in rabbits, the mean irritation score in 6 animals after 72 hours was 0.33/110.
Hence the test chemical can be considered non-irritant to rabbit eyes. - Executive summary:
In an eye irritation study in rabbits, performed according to according to USA Interagency Regulatory Liaison Group Testing Standards and Guidelines Work Group, the mean irritation score in 6 animals after 72 hours was 0.33/110.
Hence the test chemical can be considered non-irritant to rabbit eyes.
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