Registration Dossier
Registration Dossier
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EC number: 221-129-0 | CAS number: 3009-97-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions. No data on purity of test substance. No data on GLP. Only 2 animals used. Exposure time >4 hours and observation period <14 days.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- The test substance (50% suspension in water) was applied to a 2.5 x 2.5 cm application site on the back of white Vienna rabbits for 20 h under occlusive conditions. The skin was left intact. After the application time, the skin was washed with water which contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 48, 72 hours and at the end of the observation period. Findings were graded using a scheme convertable into the Draize scheme.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Anilinoacetonitrile
- EC Number:
- 221-129-0
- EC Name:
- Anilinoacetonitrile
- Cas Number:
- 3009-97-0
- Molecular formula:
- C8H8N2
- IUPAC Name:
- 2-(phenylamino)acetonitrile
- Details on test material:
- - Name of test material (as cited in study report): Phenylglycinnitril
- Physical state: solid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Duration of treatment / exposure:
- 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24,48,72
- Score:
- 0
- Remarks on result:
- other: Individual Scores of the BASF Test have been converted into the OECD Draize Scheme.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24,48,72
- Score:
- 0
- Remarks on result:
- other: Individual Scores of the BASF Test have been converted into the OECD Draize Scheme.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
