Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Emergency measure - Inhalation: Administration of oxygen or fresh air. Seek medical
attention. Medical supervision for at least 48 hours.
Emergency measure - Eyes: Flush with copious amounts of water under open eyelid for
several minutes. Protect unaffected eye. Seek medical
attention. Medical supervision for at least 48 hours.
Emergency measure - Skin: Wash affected areas with copious amounts of water. Take off
contaminated clothing immediately. Seek medical attention.
Medical supervision at least 48 hours.
Emergency measure - Ingestion: Rinse mouth with water. Afterwards drink plenty amounts of
water. Seek medical attention. Medical supervision for at
least 48 hours.

Fire-fighting measures

Recommended extinguishing agent: Adjust extinguishing operations according to the
environment.

Water, dry powder, foam and carbon dioxide (CO2).

Product arising from burning: Residues of combustion and contaminated water for fire
protection have to be disposed according to competent
authority regulations.

Product determined by test: N

Protective equipment: Circulating air independent respirator.

Avoid inhaling of evolving explosion and fire gases.

Accidental release measures

Emergency measures in case of spillage: Keep unprotected persons away.

Remove all sources of ignition.

Avoid dust formation when taking up mechanically by

using an appropriate vacuum cleaner.

Wear personnel protective equipment (see section
"Handling").

Do not release to surface water or drains.

Handling and storage

BIBR 1048 oxa-acid is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
BIBR 1048 oxa-acid is handled under Strictly Controlled Conditions as defined under REACH Article 18(4) throughout its life cycle.
Specifically the substance is rigorously contained by technical means during its whole lifecycle; procedural and control technologies are used to minimise emissions and any resulting exposures; only properly trained and authorised personnel handle the substance; special procedures such as purging and washing are applied during cleaning and maintenance works, in cases of accident and where waste is generated, proceduraland/or control technologies are used to minimise emissions and the resulting exposures; and substance-handling procedures are well documented and strictly supervised by the site operator.

Transport information

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Marine transport (IMDG)

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Exposure controls / personal protection

BIBR 1048 oxa-acid is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.
BIBR 1048 oxa-acid is handled under Strictly Controlled Conditions as defined under REACH Article 18(4) throughout its life cycle.
Specifically the substance is rigorously contained by technical means during its whole lifecycle; procedural and control technologies are used to minimise emissions and any resulting exposures; only properly trained and authorised personnel handle the substance; special procedures such as purging and washing are applied during cleaning and maintenance works, in cases of accident and where waste is generated, proceduraland/or control technologies are used to minimise emissions and the resulting exposures; and substance-handling procedures are well documented and strictly supervised by the site operator.

Stability and reactivity

Disposal considerations