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EC number: 700-425-8
CAS number: 521284-22-0
Substance tested in chicken egg membrane (in vitro), rabbit eyes (in vivo) and rabbit skin (in vivo) tests.
Mean value eye irritations scores:
Mean 24, 48 and 72 hours
The test substance was found to be not irritating to rabbit skin in an
in vivo skin irritation/corrosion test.
In an in vivo eye irritation/corrosion test, the test substance was
found to show irritation shortly after test substance instillation. The
animals had shown complete recovery by day 14 of observation.
As the test substance showed no evidence of skin irritation or corrosion
in an in vivo skin irritation/corrosion test, no classification for skin
irritation/corrosion effects are warranted for this substance.
With regards to eye irritation, as the mean score following grading at
24, 48 and 72 hours for Conjunctival redness was >/= 2 (2.15) in 2
animals which showed recovery within the observation period. One animal
was observed to have spasms shortly after instillation of the test
material and was killed for human reasons. This is not thought to be
attributed to treatment and most likely a stress reaction in a
compromised rabbit and as such it is considered that the test material
does not cause irreversible effects on the eye.
Due to the mean score for conjunctival redness, the classification as
per the CLP regulation (EC No. 1272/2008, as amended) as Irritating to
eyes (category 2) is considered appropriate for this substance
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