Registration Dossier
Registration Dossier
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EC number: 463-270-2 | CAS number: -
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-09-14 - 2015-12-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The GLP-study was performed according to an internationally accepted guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: by loss of weight or by trapping vaporisate
Test material
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
Transition / decomposition
- Transition / decomposition:
- yes
- Transition temp.:
- 60 °C
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of PHYTOSTERYL MACADAMIATE was determined following EU A.4 using the effusion method (weight loss).For the test item PHYTOSTERYL MACADAMIATE, the following vapour pressures at 20 °C and at 25 °C were calculated:
Vapour pressure at 20 °C: 1.53 * 10-04Pa
Vapour pressure at 25 °C: 2.11 * 10-04Pa - Executive summary:
The vapour pressure of the test item PHYTOSTERYL MACADAMIATE was determined at three different temperatures (30, 45, 60 and 75 °C) following EU A.4 using the effusion method (weight loss). ). In experiment 3 (nominal temperature 60 °C) the test item melted and due to the phase transition the reproducibility was not good. To avoid bias, these measurements were not used for calculations. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were also not used for calculations as well.
Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 22 % and good correlation.
For the test item PHYTOSTERYL MACADAMIATE, the following vapour pressures at 20 °C and at 25 °C were calculated:
Vapour pressure at 20 °C: 1.53* 10-04Pa
Vapour pressure at 25 °C: 2.11* 10-04Pa
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