Registration Dossier
Registration Dossier
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EC number: 942-732-1 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
No evidence of hydrolysis was observed during testing of a structurally similar substance. Although there are some differing trends observed for the test data, there is no significant evidence for degradation of the test substance over the 7 day period of the study.
Key value for chemical safety assessment
Additional information
The hydrolysis potential of 6-[(p-Tosyl)amino]hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol (1:1) was determined using a test method equivalent to OECD Guideline for Testing of Chemicals 111. 6-[(p-Tosyl)amino]hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol (1:1) differs from the registered substance with the presence of triethanolamine in place of monoethanolamine.
. Recoveries at ambient temperature and at 50°C were investigated (see 'Hydrolysis_key study_50°C' for the results of the 50°C investigation). For all pH's, the recovery at 50°C was greater than that at ambient temperature (22.4°C) which was unexpected. Possible hydrolysis/reaction products that may be expected from the test substance were suggested by the sponsor (toluene sulphonic acid and the tosyl salt ester with triethanolamine) and the specific molecular weights of these species were examined but a conclusion was made that, at the concentrations analysed, there was no evidence of the species being present at any significant level. To check for further evidence of degradation, a further timepoint was analysed after approximately 6-7 days. High recoveries were observed versus theory for the initial timepoints, especially at pH 7 and pH 9. The reason for this is not known. Although there are some differing trends observed for the test data, there is no significant evidence for degradation of the test substance over the 7 day period of the study. No evidence of hydrolysis was observed during this study. Lack of hydrolysis under the conditions of the test were expected; the only hydrolysable bond in the test substance and in the registered substance is the sulphonamide bond. This is a stable bond requiring extremes of pH and temperature for hydrolysis to occur. Under normal environmental conditions neither the pH or the temperature profile would be expected to result in the occurrence of hydrolysis.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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