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EC number: 807-130-4
CAS number: 53716-82-8
The analytically determined concentration of the test item in the
test medium at the start and end of the test was 90 and 83% of the
nominal value, respectively. Under the conditions of the test, the test
item was sufficiently stable in the test medium over the test period of
48 hours. The reported biological results were based
on the nominal concentration of the test item.
Reviewer's note: The sample has been directly injected in the
GC-FID which would result in the anhydrous form of Cyrene™
being detected, however, the organisms would have been exposed to Gem
Observations and measurements:
No remarkable observations were made concerning the appearance of
the test medium. The test medium was clear throughout the entire test
At the beginning and end of the test period, the dissolved oxygen
concentrations in the test medium and control were at least 8.3 mg/L,
the pH value of the test media was in the range of 7.8 to 7.9 and the
water temperature during the test was maintained at 21 °C.
toxicity to aquatic invertebrates:
A 48-hour EC50 value of >100 mg/l and a NOEC
of ≥100 mg/l (nominal) (highest concentration tested) (OECD 202)
A 48-hour EC50 value of >100 mg/l and a NOEC of ≥100 mg/l
(nominal) (limit test) have been determined for the effects of
(1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one (CAS 53716-82-8) on mobility
of Daphnia magna. Based on measured GC concentrations, the test
concentrations were within 80% of the nominal concentration, therefore
the results are reported in terms of nominal concentration.
In view of the properties of the substance, it is thought that the
organisms were exposed to the Gem Diol form of the substance.
Refer to IUCLID Section 6.0 and CSR Section 7.0 for further discussion
of the approach to chemical safety assessment for this registration
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