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EC number: 807-130-4
CAS number: 53716-82-8
Reliable short-term toxicity tests results are
available for freshwater fish (Oncorhynchus mykiss),
invertebrates (Daphnia magna) and algae (Scenedesmus
subspicatus) for (1S,5R-6,8-dioaxbicyclo[3.2.1]octan-4-one (Cyrene™,
CAS 53716-82-8, EC 807-130-4). The relevant short-term values are:
Fish: LC50 (96 h): >100 mg/l; NOEC: ≥100
mg/l (based on mortality) (limit test) (exposure is predominantly to the
Gem Diol form).
Daphnia: EC50 (48
h): >100 mg/l; NOEC: ≥100 mg/l (based on mobility) (limit test)
(exposure is predominantly to the Gem Diol form).
Algae: EC50 (72 h): >100 mg/l; EC10:
>100 mg/l, NOEC: ≥100 mg/l (based on growth rate) (highest concentration
tested) (exposure is predominantly to the Gem Diol form).
Activated sludge respiration inhibition: 3 hour EC50
value of >1000 mg/l (highest concentration tested) and a NOEC of
500 mg/l (nominal concentrations) have been determined for the effects
of the test substance, Cyrene™ on respiration inhibition of activated
sludge, in compliance with OECD Test Guideline 209 (exposure is
predominantly to the Gem Diol form).
In the presence of water, Cyrene™,
its keto group [C=O], gains water (H2O) to form the
corresponding Gem Diol [C(OH)2]. An equilibrium is established rapidly
and is completely reversible. The ratio of the two forms depends upon
the amount of water present. At
concentrations relevant for the environment and in vivo, the Gem
Diol form predominates. Further information (including discussion of
analytical methods used in the ecotoxicology studies) is available in
the physical and chemical properties endpoint summary (IUCLID Section 4,
CSR Section 1.4) and in the attached assessment report in Section 13 of
No long-term aquatic toxicity data are available
for fish and Daphnia. The Annex IX data requirements have
therefore been fulfilled using QSAR predicted data.
For completeness, and to compare estimated
sensitivities of the test organisms for indicative PNEC derivation,
predicted algal toxicity data have also been included as supporting
The aqueous form of the registered substance, the
Gem Diol, is the relevant species for aquatic assessment, therefore the
properties of the Gem Diol have been used as the input parameters for
The relevant predicted values, using ECOSAR v2.0
for the prediction of the aquatic toxicity of neutral organics, are:
Fish QSAR: 96-hour LC50 174058 mg/l and
30-day NOEC mg/l 6482 mg/l.
48-hour EC50 71407 mg/l and 16-day NOEC 1575 mg/l.
Algae QSAR: 96-hour EC50 13875 mg/l and
NOEC 985 mg/l.
Refer to IUCLID Section 6.0, Ecotoxicological
information, and CSR Section 7.0 for further discussion of the approach
to chemical safety assessment for this registration substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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