Registration Dossier
Registration Dossier
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EC number: 202-905-8 | CAS number: 100-97-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
Waiving of study: In accordance with column 2 of REACH Annex IX, the test on long-term toxicity to aquatic invertebrates (required in section 9.1.5) does not need to be conducted as the chemical safety assessment according to Annex I indicates no need to investigate further the effects on aquatic organisms. The following aspects need to be considered: •methenaminewas shown to be degradable (mainly hydrolysis, but also biodegradation) •methenaminewas non-toxic in the available tests using aquatic organism (up to 100 times above recommended limit concentrations) • logPowof -2.18 does not indicate a potential for bioaccumulation • one degradation product, formaldehyde, is ready biodegradable, the other degradation product, ammonia, is a naturally occurring substance known for many metabolic pathways in organisms. The environmental levels of both due to degradation ofmethenamineare very low compared to releases from other sources. Taking these findings together, a long-term exposure of aquatic organisms toecotoxicologicalrelevant concentrations ofmethenaminecan be excluded. Hence, further information concerning long-term effects on aquatic organisms is dispensable.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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