Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-193-3 | CAS number: 54-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-11-05 to 2014-11-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with standard test protocols (OECD 105 resp. EU A.6) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see "principles of method if other than guideline"
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see "principles of method if other than guideline"
- Principles of method if other than guideline:
- As the test item nicotine is very well soluble in water, it was not possible to weigh the fivefold saturation concentration of the test item in water in order to perform a main study as described in the guidelines.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: simplified flask method without analytical determination
- Water solubility:
- other: miscible with water in all proportions
- Temp.:
- 20 °C
- pH:
- >= 8 - <= 10
- Remarks on result:
- other: The test item nicotine gives an alkaline solution when mixed with water.
- Details on results:
- In none of the solutions the Tyndall effect was visible (i.e. a laser beam was not scattered when transmitted through the liquid). The test item had dissolved completely in all cases (visual judgement).
- Conclusions:
- Interpretation of results (migrated information): miscible in all proportions
- Executive summary:
The determination of the water solubility of nicotine was performed by a simplified flask method without analytical determination.
After mixing 1 g and 10 g of the test item, respectively, with 0.1 mL, 1 mL, 2 mL, 5 mL, and 10 mL of H2O at room temperature, the test item nicotine was completely dissolved (visual judgement).
The results of the test indicated that nicotine is miscible with water in all proportions. Thus, it is not possible to weigh the fivefold saturation concentration of the test item in water in order to perform a main study. The main study as described in the guidelines is therefore not necessary in this case.
In conclusion, nicotine was considered to be miscible with water in all proportions at room temperature, and no further testing was performed.
Reference
Observations during the evaluation of the water solubility of nicotine at room temperature:
Test Item [g] |
H2O [mL] |
Appearance |
Test Item [g] |
H2O [mL] |
Appearance |
1 |
0.1 |
clear liquid, no Tyndall effect |
10 |
0.1 |
clear liquid, no Tyndall effect |
1 |
1 |
clear liquid, no Tyndall effect |
10 |
1 |
clear liquid, no Tyndall effect |
1 |
2 |
clear liquid, no Tyndall effect |
10 |
2 |
clear liquid, no Tyndall effect |
1 |
5 |
clear liquid, no Tyndall effect |
10 |
5 |
clear liquid, no Tyndall effect |
1 |
10 |
clear liquid, no Tyndall effect |
10 |
10 |
clear liquid, no Tyndall effect |
Description of key information
Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.
Key value for chemical safety assessment
- Water solubility:
- 100 000 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.