Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-193-3 | CAS number: 54-11-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a standard procedure, but not according to a guideline. Not all details on the study performance are reported.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Shake-flask method, see details on method in the reference document.
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -2.67
- pH:
- 2.01
- Remarks on result:
- other: temperature is not stated in the reference
- Type:
- log Pow
- Partition coefficient:
- 0.28
- pH:
- 7.4
- Remarks on result:
- other: temperature is not stated in the reference
- Type:
- log Pow
- Partition coefficient:
- 1.17
- pH:
- 12.17
- Remarks on result:
- other: temperature is not stated in the reference
- Executive summary:
The octanol/water partition coefficient of nicotine was determined by the traditional shake-flask method at different pH values. The commom logarithm values of the determined partition coefficient (log Pow) correspond to -2.67 (pH 2.01), 0.28 (pH 7.4), and 1.17 (pH 12.17).
In a further study, a log Pow value of 1.17 at pH 11 (with the Sörensen buffer solution (Na2B4O7 - NaOH) as aqueous phase) was determined for nicotine. For details, see Fujita, T., Nakajima, M., Soeda, Y. and Yamamoto, I., "Physicochemical properties of biological interest and structure of nicotine and its related compounds", Pestic. Biochem. Physiol., 1971, 1, 151 -162.
Reference
Description of key information
Results were reported in literature. The results are reliable with restriction. Key study is appropriate for the risk assessment.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.17
- at the temperature of:
- 18 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
