2-chloropropane

Short-term toxicity to fish

Description of key information

LC50 values for IPC in Danio rerio, based on the initial concentrations of the test article were reported to be: LC50 (72 hrs) = 159.9 mg/L and (96 hrs) = 159.9 mg/L. Corrected LC50 based on the calculated average effective concentration of ca. 60% of the initial test article concentration and 10% mortality rate in the vehicle control; 72 h LC50 = 113.8 mg/L, 96 h LC50 = 113.8 mg/L.

Danio rerio (reported as Brachydanio rerio): LC50 (72 and 96 hours) = 189.7 mg/L (from nominal concentrations) or 113.8 mg/L (from 60% of nominal concentrations)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

113.8 mg/L

Additional information

One acute toxicity study was performed to assess the acute toxicity of IPC to the freshwater fish species Danio rerio (reported as Brachydanio rerio) (Thun, 1990). The study was conducted under GLP and according to OECD Guideline 203; however, the body weights of the test animals were not reported. The study also followed the EEC Directive 79/831 Annex V guidelines. The study was conducted in a semi-static system, and the test substance was replenished every 24 hours on the basis that IPC is volatile. In their calculation of the LC50 values, the authors appear not to have taken into account the 10% mortality that occurred in the vehicle control group (10% Tween 80) at 48, 72 and 96 hours. When the 10% mortality in the vehicle control is considered, the LC0 values increase in the following manner: 48 hr LC0 = 260 mg/L (nominal) or 156 mg/L (60% of the nominal concentration); 72 hr LC0 = 100 mg/L (nominal) or 60 mg/L (60% of the nominal concentration); 96 hr LC0 = 100 mg/L (nominal) or 60 mg/L (60% of the nominal concentration). Furthermore, the alternative interpretation of the LC0 values increases the calculated LC50 values to the following: 72 and 96 hr LC50 = 189.7 mg/L (from nominal concentrations) or 113.8 mg/L (from 60% of nominal concentrations).