Registration Dossier
Registration Dossier
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EC number: 200-858-8 | CAS number: 75-29-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- The skin
sensitisation potential of isopropyl chloride was assessed in a
GLP-compliant study performed according to OECD Guideline for the Testing
of Chemicals No. 406 (Fürst, 1989). In this study, the induction period
consisted of intradermal injections and an epicutaneous application. Three
pairs of intradermal injections (0.05 mL) were administered to the back of
Pirbright Dunkin Hartley guinea pigs (20 animals in the test group and 10
animals in the control group). The 3 injections were composed of the
following: 10% isopropyl chloride in vehicle (oleum arachidis), 10%
isopropyl chloride in Freund's Adjuvant complete (FCA), or undiluted FCA. The
control animals received the vehicle instead of the test compound. After 1
week, a single epicutaneous application of 0.5 mL isopropyl chloride
(0.75% in oleum arachidis) was applied for a period of 48 hours. During
the challenge period (2 weeks following epicutaneous application), 0.5 mL
of isopropyl chloride (75% in Oleum arachidis) was applied to the flank
for a period of 24 hours. Control animals were challenged with the vehicle
only. No sensitisation reactions were reported at 24 and 48 hours for the
test or control animals. It should be noted that the results of a recent
positive control test were not reported; however, the results of this test
are considered reliable. Therefore, the test compound isopropyl chloride
was considered not to cause contact hypersensitivity in guinea pigs.
Migrated from Short description of key information:
Isopropyl chloride was reported to be non-sensitizing to guinea pig skin in a sensitisation test, which was conducted in a GLP-compliant study and performed according to test guidelines.
Justification for classification or non-classification
There is no information available concerning respiratory sensitisation.
According to OECD TG 406 the submission substance is not a skin sensitizer. As a result, the substance does not meet the criteria for classification according to Regulation (EC) No 1272/2008, Annex I section 3.4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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