Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-081-7 | CAS number: 78-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1993-11-18 to 1993-12-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was well documented and meets generally accepted scientific principles, and conducted in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: Test for inhibition of oxygen consumption by pseudomonas putida -Huels Method
- Principles of method if other than guideline:
- Method: Oxygen consumption test (Huls method)
- GLP compliance:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: nonylphenol ethoxylated propoxylated (EO 10Mol PO 5Mol) used as solubilising agent - Test organisms (species):
- Pseudomonas putida
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 5 h
- Post exposure observation period:
- At the end of testing HCl was added to stop biochemical processes.
- Test temperature:
- 23.9-25.1°C
- Nominal and measured concentrations:
- 500,1000, 1500 and 2000 µl/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: 100mL glass bottles with ground glass stopper
- No. of vessels per concentration (replicates): Four, two containing HgCl2
- No. of vessels per control (replicates): Nine, four containing HgCl2
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : oxygen content of solutions measured using oxygen electrode. - Reference substance (positive control):
- no
- Duration:
- 5 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.1 other: ml/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- Measured data was not available for triethoxy(vinyl)silane. Therefore read across of data from the comparable substance, trimethoxyvinylsilane was considered. A EC10 of 1.1 ml/l for toxicity to microorganisms were determined in a reliable study conducted in compliance with GLP.
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature (Handbook). The original reference was not available for review and no further information is available.
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA guidelines
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test organisms (species):
- other: Non-acclimated bacteria
- Dose descriptor:
- IC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- An IC 50 value of > 1000mg/l for non-acclimated bacteria is reported in secondary literature (Handbook). The original reference was not available for review and no further information is available. The reliability of this result is not assignable.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to overall summary (IUCLID Section 6.1) and attached justification for grouping in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 5 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.1 other: ml/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Referenceopen allclose all
|
Oxygen concentration (µl/L) |
||||
Control |
Test substance at concentration: |
||||
500µl/L |
1000µl/L |
1500µl/L |
2000µl/L |
||
Flasks with HgCl2at beginning of test |
7.97 |
|
|||
7.92 |
|||||
7.84 |
7.77 |
7.68 |
7.57 |
7.59 |
|
7.87 |
7.81 |
7.70 |
7.66 |
7.50 |
|
Average value |
7.90 |
7.79 |
7.69 |
7.62 |
7.55 |
Flasks without HgCl2at end of test |
3.79 |
|
|||
3.74 |
|||||
3.81 |
3.78 |
3.93 |
4.05 |
4.12 |
|
3.81 |
3.84 |
4.06 |
4.25 |
4.05 |
|
Average value |
3.79 |
3.81 |
4.00 |
4.15 |
4.09 |
O2Consumption during incubation |
4.11 |
3.98 |
3.70 |
3.47 |
3.46 |
Absolute difference during incubation |
|
0.13 |
0.42 |
0.64 |
0.65 |
% effect during incubation |
|
3.2 |
10.2 |
15.7 |
15.9 |
Description of key information
NOEC of 100 mg/l (OECD 301F)
EC10 of 1.1 ml/l (1.1. ml = ca 1g calculated from density; RL2)
Key value for chemical safety assessment
Additional information
The toxicity of triethoxy(vinyl)silane (CAS 78-08-0) to microorganisms was reported in secondary literature, with an IC50 of > 1000 mg/l (Chandra, 1997). However no further information is available and therefore the results are not reliable and can be used only as supportive information.
As no reliable data were available for triethoxy(vinyl)silane (CAS 78-08-0), data were read across from the analogue substance, trimethoxy(vinyl)silane (CAS 2768-02-7). Both substances share the same silanol hydrolysis product, vinylsilanetriol. Further hydrolysis products are ethanol and methanol respectively. Ethanol and methanol are readily biodegradable, are well characterised and are not expected to have adverse effects on microorganisms in a sewage treatment plant. Both triethoxy(vinyl)silane (CAS 78-08-0) and trimethoxy(vinyl)silane (CAS 2768-02-7) are within an analogue group of substances that exhibit no evidence of significant toxicity to microorganisms. It is therefore considered valid to read-across the results for trimethoxy(vinyl)silane to fill the data gap for the target substance.
One study testing the respiration inhibition of the single organism Pseudomonas putida by trimethoxy(vinyl)silane is available (Hüls AG, 1993c). The study resulted in an EC10 of 1.1 ml/l (1.1. ml = ca 1g calculated from density) based on oxygen consumption. The study was conducted in compliance with GLP.
Good quality data for the analogue substance, trimethoxy(vinyl)silane (CAS 2768-02-7), have been read across from the biodegradation study. The reliable biodegradation study was performed according to OECD 301 F. The biodegradation rate in the toxicity control shows a similar course of biodegradation as the two controls containing the reference item, only. Within 14 days of exposure, a biodegradation of 64% of the reference substance was observed. Thus, according to guideline the test item shows no inhibitory effect on activated sludge microorganisms up to a concentration of 100 mg/l. The NOEC of 100 mg/l can be used for the PNEC derivation. It can be concluded that inhibition of the degradation activity of activated sludge is not anticipated due to the results of the biodegradation study and the single organisms is not used for the evaluation of a sewage treatment plant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.