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EC number: 469-910-7 | CAS number: 847842-48-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional physico-chemical information
Administrative data
Link to relevant study record(s)
Description of key information
Studies conducted on the substance of interest Abacavir Glutarate
Minimum ignition temperature-powder layer: No ignition or exotherm observed up to 400°C
Studies conducted on the analogue substance Abacavir Hemisulphate
Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996): Minimum ignition temperature of dispersed dust was determined to be 570°C.
Minimum Ignition Energy Measurement - (Weaver, 1996): Based on the results the test material can be considered to be moderately sensitive to ignition from electronic discharges when in the form of a dust cloud.
Powder Volume Resistivity - (Weaver, 1996): The test material has a powder volume resistivity at ambient relative humidity (relative humidity 42% , 21°C) of 2.2 X 10 E-12 Ωm. The test material has a powder volume resistivity at low relative humidity (relative humidity <10%, 19°C) 1.5 X 10 E-14 Ωm.
Charge Relaxation Time - (Weaver, 1996): Charge Relaxation Time (Ambient relative humidity 42%): 10.2 minutes; Charge Relaxation Time (Low relative humidity <10%): 2.54 hours.
Studies conducted on the analogue substance Abacavir Succinate
Minimum Ignition Energy Measurement - (Weaver, 1996): Minimum Ignition Energy: 70 - 80 mJ. Based on the results the test material can be considered to have minimal sensitivity to ignition from electronic discharges when in the form of a dust cloud.
Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996): The minimum ignition temperature of dispersed dust was determined to be 460°C.
Powder Volume Resistivity - (Weaver, 1996): The test material has a powder volume resistivity at ambient relative humidity (relative humidity 43% , 23°C) of 4.0 X 10 E8 Ωm. The test material has a powder volume resistivity at low relative humidity (relative humidity <10%, 34°C) 3.3 X 10 E9 Ωm.
Charge Relaxation Time - (Weaver, 1996): The charge relaxation time of the test material at both ambient and low relative humidity is < 1 second.
Additional information
A number of physical-chemical studies have been carried out on both the substance of interest, Abacavir Glutarate, and the analogue materials Abacavir Hemisulphate and Abacavir Succinate.
The studies were conducted for risk assessment purposes for use in the workplace and transport. They are not conducted to OECD standard and in some cases are not GLP compliant.
Based on these obsversations, the studies cannot be considered to be reliable and are included here for information purposes only.
Study conducted on the substance of interest Abacavir Glutarate
Minimum Ignition Temperature (Layer) - (Gilmore, 2003)
The test was performed in accordance with SOP LP-08. The test was performed using a controlled hot plate and Pico Log data acquisition system. The SOP is based on IEC Standard 1241 -2 -1, Part 2.
Minimum ignition temperature (powder layer): No ignition or exotherm observed up to 400°C.
Studies conducted on the analogue substance Abacavir Hemisulphate
Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996):
The test was performed in accordance with IEC 1241-2-1 Electrical Apparatus for use in the presence of Combustible Dusts. Part 2. Method B.
Ignition produced bright, orange flames and no visible smoke and the Minimum ignition temperature of dispersed dust was determined to be 570°C.
Minimum Ignition Energy Measurement - (Weaver, 1996):
The test was performed in accordance with BS 5958: Part I (1991) or the German VDI organisation (Fortschritt-Berichte VDI, Reihe 3: Verfahrenstechnik Nr 134). The test was performed using a vertical tube apparatus.
Based on the results the test material can be considered to be moderately sensitive to ignition from electronic discharges when in the form of a dust cloud.
Powder Volume Resistivity - (Weaver, 1996):
Based on the test results the teat material can be considered to have a powder volume resistivity at ambient relative humidity of >1012
Ωm and a powder volume resistivity at low relative humidity of >1014Ωm and is therefore considered to be insulating.
Charge Relaxation Time - (Weaver, 1996):
A study carried out to establish the charge relaxation time of the test material produced the following conclusions:
Charge Relaxation Time (Ambient relative humidity 42%): 10.2 minutes
Charge Relaxation Time (Low relative humidity < 10%): 2.54 hours
Studies conducted on the analogue substance Abacavir Succinate
Minimum Ignition Energy Measurement - (Weaver, 1996):The test was performed in accordance with BS 5958: Part I (1991). The test was performed using a vertical tube apparatus.
Minimum Ignition Energy: 70 - 80 mJ.
Based on the results the test material can be considered to have minimal sensitivity to ignition from electronic discharges when in the form of a dust cloud.
Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996):
The test was performed in accordance with IEC 1241-2-1 Electrical Apparatus for use in the presence of Combustible Dusts. Part 2. Method B.
Ignition produced a bright, orange flame and small quantities of grey smoke. The minimum ignition temperature of dispersed dust was determined to be 460°C.
Powder Volume Resistivity - (Weaver, 1996):
Based on the test results the teat material can be considered to have a powder volume resistivity at ambient relative humidity in the range of 106Ωm and 1012Ωm and a powder volume resistivity at low relative humidity in the range of 106Ωm and 1012Ωm
and is therefore considered to be borderline to being conductive.Charge Relaxation Time - (Weaver, 1996):
A study carried out to establish the charge relaxation time of the test material produced the following conclusions:
Charge Relaxation Time (Ambient relative humidity 43%): < 1 second
Charge Relaxation Time (Low relative humidity < 10%): < 1 second
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