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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: no data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Review article with only results presented. Only Secondary Source reviewed.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Occupational Respiratory Diseases.
Author:
Merchant JA (ed).
Year:
1986
Bibliographic source:
DHHS (NIOSH) Publication No. 86-102 : 438-444.
Reference Type:
publication
Title:
Pneumoconiosis in the tungsten carbide tool industry.
Author:
Miller CW , Davis MW, Goldman A, and Wyatt JP.
Year:
1953
Bibliographic source:
AMA Arch Ind Hyg Occ Med 8:453-465.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data available on principles of method
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
other: intratracheal
Vehicle:
not specified
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data

Examinations

Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
Rats exposed to tungsten metal showed a mild interstitial and perivascular inflammatory cell response. Increased collagen tissue was noted by eight months. Tungsten caused mild interstitial fibrosis following intratracheal injection.

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion