Registration Dossier
Registration Dossier
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EC number: 231-143-9 | CAS number: 7440-33-7
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Review article with only results presented. Only Secondary Source reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Occupational Respiratory Diseases.
- Author:
- Merchant JA (ed).
- Year:
- 1 986
- Bibliographic source:
- DHHS (NIOSH) Publication No. 86-102 : 438-444.
- Reference Type:
- publication
- Title:
- Pneumoconiosis in the tungsten carbide tool industry.
- Author:
- Miller CW , Davis MW, Goldman A, and Wyatt JP.
- Year:
- 1 953
- Bibliographic source:
- AMA Arch Ind Hyg Occ Med 8:453-465.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data available on principles of method
- GLP compliance:
- no
Test material
- Reference substance name:
- Tungsten
- EC Number:
- 231-143-9
- EC Name:
- Tungsten
- Cas Number:
- 7440-33-7
- Molecular formula:
- W
- IUPAC Name:
- tungsten
- Reference substance name:
- Tungsten Metal
- IUPAC Name:
- Tungsten Metal
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- other: intratracheal
- Vehicle:
- not specified
- Details on exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
Examinations
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- Rats exposed to tungsten metal showed a mild interstitial and perivascular inflammatory cell response. Increased collagen tissue was noted by eight months. Tungsten caused mild interstitial fibrosis following intratracheal injection.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
