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EC number: 231-143-9
CAS number: 7440-33-7
Assessment of metabolic activity demonstrated increasing toxicity with
increasing tungsten concentrations in all cell lines examined. However,
marked differences in susceptibility were found. Pulmonary arterial
endothelial and smooth muscle cells showed a significant decrease in
metabolic activity in relation to incubation time and incubation
concentrations. In contrast, fibroblasts kept their metabolic activity
despite prolonged exposure time. At a threshold tungsten level of 50
ug/ml, all cell types showed a decrease in metabolic activity and as
before, fibroblasts were more resistant to higher tungsten levels in the
culture medium. The highest toxicity of tungsten was demonstrated for
human pulmonary arterial endothelial cells. The LD50 was 50 ug/ml for
human pulmonary arterial endothelial cells, 100 ug/ml for human
pulmonary smooth muscle cells and 1000 ug/ml for human dermal
fibroblasts. In endothelial cells, irrespective of incubation time, a
tungsten level of 500 ug/ml in the growth medium lead to complete cell
death as reflected by the steep decrease of metabolic activity if
compared to unexposed control cells regardless of incubation time. In
pulmonary arterial smooth muscle cells, metabolic activity gradually
decreased in relation to incubation time and this observation was
pronounced with increasing tungsten concentrations in the culture
medium. In contrast, fibroblasts retained their metabolic activity up to
a tungsten concentration of 1000 ug/ml before they showed a marked
decrease in metabolic activity.
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