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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
biotransformation and kinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: Quantification of metabolites formed during degradation of 2-butoxyethanol
- Short description of test conditions: 3hrs exposure, then collection of metabolites by solvent extraction
- Parameters analysed / observed: Analysis of metabolites by GC-MS.
GLP compliance:
not specified
Type of medium:
aquatic

Test material

Constituent 1
Chemical structure
Reference substance name:
2-butoxyethanol
EC Number:
203-905-0
EC Name:
2-butoxyethanol
Cas Number:
111-76-2
Molecular formula:
C6H14O2
IUPAC Name:
2-butoxyethanol

Results and discussion

Transformation products:
yes
Identity of transformation productsopen allclose all
No.:
#1
Reference
Reference substance name:
Unnamed
IUPAC name:
butoxyacetic acid
No.:
#2
Reference
Reference substance name:
Unnamed
IUPAC name:
butan-1-ol
Inventory number:
InventoryMultipleMappingImpl [inventoryEntryValue=EC 200-751-6]
CAS number:
71-36-3
Identity:
1-Butanol
Molecular formula:
C4H10O
Molecular weight:
74.122
SMILES notation:
CCCCO
InChl:
InChI=1/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3
No.:
#3
Reference
Reference substance name:
Unnamed
IUPAC name:
sodium butyrate
Inventory number:
InventoryMultipleMappingImpl [inventoryEntryValue=EC 205-857-6]
CAS number:
156-54-7
Identity:
Butanoic acid, sodium salt
Molecular formula:
C4H8O2.Na
Molecular weight:
110.087
SMILES notation:
[Na+].CCCC(=O)[O-]
InChl:
InChI=1/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

Any other information on results incl. tables

As well as the transformation products, unchanged 2 -butoxyethanol was also detected.

This study was part of a larger study that examined the potential of 11 bacterial strains to degrade 2 -butoxyethanol. This particular species/strain grew the fastest and tolerated the highest substrate concentrations among the strains/species examined (and hence why it was used for this metabolite study). The maximum growth rate was 0.645 h-1 at a concentration of 5 mM (590mg/L), which was completely degraded within less than 6 h. A stable degradation of 2-BE could be achieved for concentrations of up to 30 mM (3540mg/L). Beyond that value, 2 -butoxyacetic acid

accumulated and the pH decreased to 6, inhibiting further growth.

.

Applicant's summary and conclusion

Executive summary:

In a study that qualitatively measured the metabolites produced by bacterial degradation of 2 -butoxethanol, the bacterial strain Pseudomonas vancouverensis was found to produce the metabolites 2 -butoxyacetic acid, butanol and butanoic acid. These findings support the hypothesis that 2 -butoxyethanol degradation by bacteria in the environment proceeds by initial oxidation to 2 -butoxyacetic acid (as in mammals) followed by cleavage of the ether group to produce butanol and butanoic acid. The maximum growth rate was 0.645 h-1 at a concentration of 5 mM (590mg/L), which was completely degraded within less than 6 h. A stable degradation of 2-BE could be achieved for concentrations of up to 30 mM (3540mg/L).