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EC number: 200-860-9 | CAS number: 75-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only one dose level tested
- GLP compliance:
- yes
Test material
- Reference substance name:
- Isopropylamine
- EC Number:
- 200-860-9
- EC Name:
- Isopropylamine
- Cas Number:
- 75-31-0
- Molecular formula:
- C3H9N
- IUPAC Name:
- propan-2-amine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Isopropylamine
- Physical state: liquid
- Analytical purity: 99.9 %
- Lot/batch No.: 561211
- Storage condition of test material: refrigerator
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. THOMAE GmbH, Biberach, Germany
- Age at study initiation: young adult animals
- Weight at study initiation: Animals of comparable weight (200 - 300 g)
- Housing: singly in stainless stell wire mesh cages, Type DK-III
- Diet: KLIBA-Labordiaet 343, Klingenthalmuehle AG, Switzerland, ad libitum
- Water: water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: aqua bidest
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 cm2
- Type of wrap if used: Four layers of absorbent gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing with warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Concentration (if solution): 10 % - Duration of exposure:
- 24 h
- Doses:
- 400 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Several times at the day of application and at least once daily therafter.
- Frequency of weighing: Shortly before application, weekly thereafter and at the end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 400 mg/kg bw
- Based on:
- act. ingr.
- Remarks:
- (10% dilution in water because of corrosivity)
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 400 mg/kg bw
- Based on:
- act. ingr.
- Remarks:
- (10% dilution in water because of corrosivity)
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: On the day of application the animals showed the following syptoms: dyspnoea, apathy, staggering, spastic gait, tremor, piloerection, exophthalmos and poor general state.
- Gross pathology:
- Sacrificed animals:
Organs: no pathologic findings noted.
Skin: full thickness necrosis (4 males/4 females), superficial necrosis (1 female), superficial crust formation (1 male)
Any other information on results incl. tables
The acute dermal LD50 of the test material was found to be greater than 400 mg/kg bw for the male und female animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the mean LD50 in male and female rats was > 400 mg/kg bw
- Executive summary:
Acute dermal toxicity was investigate in male and female Wistar rats (5 animals per sex). Application of 400 mg/kg test item (applied as 10% dilution in water) for 24 hours under semi-occlusive conditions did not cause lethal effects. On the day of application animals showed dyspnoea, apathy, staggering, spastic gait, tremor, piloerection, exophthalmos and poor general state. The diluted test material caused full thickness necrosis in 4/4 females and 4/4 males.
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