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EC number: 204-528-4
CAS number: 122-20-3
toxicity to fish
as presented by a BASF AG study from 1987 indicate that the test
substance is not harmful to fish. The 96 -h LC50 value calculated as
geometrical mean is 3158 mg/L. Results are supported by an acute toxicty
test according to EU Method C.1 (Acute Toxicity for Fish) from Hüls
(1997). In the limit-test no mortality was observed at 1000 mg/L (LC50
(96 h) >1000 mg/L, nominal confirmed by concentration control
toxicity to fish
The long-term toxicity to fish is derived
using the Acute-to-Chronic (ACR) approach. Based on the available 96-h
LC50 of 3158 mg/L (BASF AG, 1987) a NOEC for the long-term toxicity to
fish of 32 mg/L was derived.
toxicity to invertebrates
as presented in a BASF AG study conducted in 1987 indicate that the test
substance is with high probability not acutely harmful to aquatic
invertebrates. The EC50 based on mobility was determined to be > 500
are supported by an acute toxicty test according to EU Method C.2 (Acute
Toxicty for Daphnia) from Hüls (1997). The EC50 (48 h) was measured to
be 857 mg/L (nominal, analytically verified).
toxicity to aquatic invertebrates
The long-term toxicity on aquatic
invertebrates has been assessed using the OECD QSAR Toolbox v4.4. A 21-d
NOEC for reproduction of Daphnia magna was derived using a trend
analysis of the standardized workflow for ecotoxicological endpoints as
provided by the Toolbox. The resulting 21-d NOEC was 27.5 mg/L. The
Substance is within the applicability domain of the model. A robust
study summary for this endpoint has been provided, which contains all
relevant and required information. Therefore, a study on the long-term
toxicity to aquatic invertebrates will not be performed.
to aquatic algae
In order to
determine the effects of 2-Propanol, 1,1',1''-nitrilotris- (CAS
122-20-3) on aquatic algae, there are experimental data from a study
sponsored by Sasol Germany GmbH (1997; formerly Huels GmbH) available.
In a test according to EU method C.3 with Desmodesmus subspicatus the
72-h ErC50 was determined to be 710 mg/L, the 72-h ErC10 was found to be
9.4 mg/L. In a supporting study by BASF (1990) the ErC50, recalculated
from the fluorescence data, after 72 hours of exposure was determined to
be > 100 mg/L.
one valid study according to ISO 8192 available (BASF AG, 1981). The
study resulted in an EC20 value of > 1995 mg/L. However the test was
performed using industrial activated sludge. According to the "Guidance
on information requirements and chemical safety assessment, chapter
R.7b: Endpoint specific guidance, point R.22.214.171.124" industrial activated
sludge is considered to be adapted to the test substance and the results
can not be extrapolated to domestic activated sludge. Hence the results
can not be used for a hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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