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EC number: 204-528-4
CAS number: 122-20-3
Table 1: Irritant/corrosive response
data for each animal at each observation time
Score at time point
Max. score: 4
Max. score: 2
Max. score: 3
In an acute eye irritation study according to OECD 405, six (3 female, 3
male) small white russian rabbits were treated with the undiluted test
subtance. The substance was applied to the eye for an exposure of 72
hours. The untreated eye was assigned as the control. After 72 hours the
eye was washed with warm physiological saline. According to the Draize
score the eyes were observed and scored 1, 24, 48 and 72 hours, and 5,
7, 10, 12, 14, 19 and 21 days after application. Effects on the cornea,
iris, conjunctivae and chemosis were observed in all animals. For 5
animals, the effects were reversible within 10 days (cornea opacity,
chemosis and effects on the iris) or at least 12 days (conjunctivae
score). The effects were not reversible in one animal after 21 days and
were severe, e.g. scores up to 3 for the paramter of the cornea.
TIPA was determined to be a severe irritant, resulting in effects that
were not reversible within 21 days in one animal out of a group of 6.
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