Registration Dossier
Registration Dossier
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EC number: 231-977-3 | CAS number: 7783-06-4
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Exposure to hydrogen sulfide and respiratory function
- Author:
- Jappinen P, Vilkka V, Marttila O, et al.
- Year:
- 1 990
- Bibliographic source:
- Br. J. Ind. Med. 47: 824-828
- Reference Type:
- secondary source
- Title:
- Hydrogen sulfide - Interim acute exposure guideline levels (AEGLs) for NAS/COT suncommittee for AEGLs
- Author:
- Anonymous
- Year:
- 2 002
- Bibliographic source:
- http://www.epa.gov/oppt/aegl/pubs/hydrogen_sulfide_interim_nov_2002.pdf
Materials and methods
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
- Molecular formula:
- H2S
- IUPAC Name:
- hydrogen sulfide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A group of 10 asthmatics (3 men age 33-50 and 7 women age 31-61) was exposed to 2 ppm hydrogen sulfide for 30 minutes. The subjects had been diagnosed bronchial asthmatics for 1 to 13 years and were under medical supervision. Severe asthmatics were excluded from the protocol. Two of the volunteers were exposed simultaneously in a 10m3 sealed tile walled exposure chamber with an oxygen flow of 2 L/min. Hydrogen sulfide concentration was monitored continuously with a sulfur dioxide analyzer connected to a converter that transformed hydrogen sulfide into sulfur dioxide at 840°C. The hydrogen sulfide was supplied to the chamber from laminated plastic bags through plastic tubing. All asthmatic subjects complained of an unpleasant odor and nasal and pharyngeal dryness at initiation of exposure. Three of the ten complained of headache after exposure. There were no significant effects on FVC, FEV1, or FEF values after exposure to hydrogen sulfide. Airway resistance (Raw) value was slightly decreased in two and increased in eight subjects. The range of Raw differences was -5.95% to +137.78 % with an average increase of 26.3%; no accompanying clinical symptoms were observed. The range of specific airway conductance (SGaw) differences was -57.7% to +30%, with an average decrease of 8.4%. These effects were not statistically significant; however, in two subjects, changes were greater than 30% in both Raw and Sgaw.
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