Registration Dossier
Registration Dossier
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EC number: 231-977-3 | CAS number: 7783-06-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: standard study design, Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effects of 10 ppm hydrogen sulfide inhalation on pulmonary function in healthy men and women
- Author:
- Bhambhani,Y, Burnham R, Snydmiller G, et al.
- Year:
- 1 996
- Bibliographic source:
- J. Occup. Environ. Med. 38, 1012-1017
- Reference Type:
- secondary source
- Title:
- Hydrogen sulfide - Interim acute exposure guideline levels (AEGLs) for NAS/COT subcommittee for AEGLs
- Author:
- Anonymous
- Year:
- 2 002
- Bibliographic source:
- http://www.epa.gov/oppt/aegl/pubs/hydrogen_sulfide_interim_nov_2002.pdf
Materials and methods
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
- Molecular formula:
- H2S
- IUPAC Name:
- hydrogen sulfide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
19 healthy volunteers (9 men, 43 age 27.4 +/- 6.4 yr and 10 women, age 21.8 +/- 3.0 yr) were exposed to 0 or 10 ppm hydrogen sulfide for 15 minutes while exercising on a cycle ergonometer at 50% of their VO2max. The exposure protocol is essentially identical to that described by Bhambhani and Singh (1991). There were no treatment-related effects on FVC, FEV1, peak expiratory flow rate, forced expiratory flow rate, or maximal ventilation volume in either sex.
In another study, 28 healthy volunteers (15 men, age 23.4 +/- 5.2 yr and 13 women, age 21.8 +/- 3.0 yr) were exposed to 0 or 10 ppm hydrogen sulfide for 30 minutes while exercising on a cycle ergonometer at 50% of their VO2max. The exposure protocol is essentially identical to that described by Bhambhani and Singh (1991). There were no treatment-related effects on oxygen uptake, carbon dioxide production, respiratory exchange ratio, heart rate, blood pressure, arterial blood oxygen and carbon dioxide tensions. Muscle lactate increased 33% (n.s.) in men and 16% (n.s.) in women after exposure to hydrogen sulfide. Muscle cytochrome oxidase decreased by 16% in men, whereas it increased by 11% in women after exposure to hydrogen sulfide. None of the subjects reported any adverse health effects subsequent to hydrogen sulfide exposure.
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