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EC number: 202-196-5 | CAS number: 92-84-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-12-30 to Feb 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- GLP declaration attached to full study report.
Test material
- Reference substance name:
- Phenothiazine
- EC Number:
- 202-196-5
- EC Name:
- Phenothiazine
- Cas Number:
- 92-84-2
- Molecular formula:
- C12H9NS
- IUPAC Name:
- 10H-phenothiazine
- Details on test material:
- - Label: CA 794
- Desciption: pale yellow coloured crystalline solid
- Date of arrival: 28 November 1986
- Storage conditions: room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Source: Nottingham University, School of Agriculture, Sutton Bonington, Leichestershire, UK and David Percival, Moston, Sandbach, Cheshire, UK
- Weight at start of study: 2.86 - 3.25 kg
- Age at start of study: 12 - 16 weeks
- Acclimatisation: min 5 days
- Identification: Ear mark and cage label
- Housing: Suspended metal cages
- Diet: Rabbit Diet, Preston Farmers Ltd., New Leake, Boston, Lincolnshire, UK, ad libitum
- Water: drinking water, ad libitum
- Room temperature: 17 - 18°C
- Relative humidity: 45 - 50 %
- Air exchange rate: 15 per hour
- Lighting: 12 hours light, 12 hours darkness
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: yes: Untreated eye was used as control.
- Amount / concentration applied:
- - A volume of 0.1 ml of the test material which was found to weigh 86.6 mg
- Duration of treatment / exposure:
- acc. to guideline.
- Observation period (in vivo):
- 1 hour, 24, 48 and 72 hours following treatment.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM:
Scoring according to Draize J.H., 1959 Association of Food and Drug Officials of the United States, Austin, Texas, "The Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics".
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hrs
- Remarks on result:
- other: Max. score @ 1hr
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hrs
- Remarks on result:
- other: Max. score @ 1hr
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hrs
- Remarks on result:
- other: Max. score @ 1hr
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- Iridial inflammation was confined to two treated eyes one hour after treatment. No iridal effects were noted at subsequent observations.
Conjunctival irritation was noted in all treated eyes one hour after treatment and at the 24 hour observation, but was confined to minimal conjunctival redness in one treated eye at the 48-hour observation. All treated eyes were normal at the 72-hour observations.
Any other information on results incl. tables
Individual and mean scores for Cornea, Iris & Conjunctivae
Rabbit number |
Time after treatment [h] |
Cornea opacity |
Iridial effects |
Conjunctival redness |
Conjunctival chemosis |
124 |
1 |
0 |
0 |
2 |
1 |
24 |
0 |
0 |
1 |
0 |
|
48 |
0 |
0 |
1 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
TOTAL 24, 48 & 72 hrs |
0 |
0 |
2 |
0 |
|
Mean * |
0.0 |
0.0 |
0.7 |
0 |
|
137 |
1 |
0 |
1 |
2 |
1 |
24 |
0 |
0 |
1 |
0 |
|
48 |
0 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
TOTAL 24, 48 & 72 hrs |
0 |
0 |
1 |
0 |
|
Mean * |
0.0 |
0.0 |
0.3 |
0.0 |
|
135 |
1 |
0 |
1 |
2 |
1 |
24 |
0 |
0 |
1 |
0 |
|
48 |
0 |
0 |
0 |
0 |
|
72 |
0 |
0 |
0 |
0 |
|
TOTAL 24, 48 & 72 hrs |
0 |
0 |
1 |
0 |
|
Mean * |
0.0 |
0.0 |
0.3 |
0.0 |
|
(*) Individual mean of 24, 48 and 72-hour readings |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was found to be non-irritant to the rabbit eye according to EEC labelling regulations and requires no symbol or risk phrase.
- Executive summary:
Summary
The potential for eye irritation/corrosion of the test substance was investigated by applying the test substance to the eyes of 3 New Zealad White rabbits.
No evidence of eye irritation was noted during the study period.
The test material was found to be a non-irritant to the rabbit eye according to the EEC labelling regulations and requires no symbol or risk phrase.
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