Registration Dossier
Registration Dossier
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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A skin sensitisation test (Batelle Institut E.V., Frankfurt) was cited in the NONS Registration dossier (Mitsui & Co., Benelux, 1991) for NC-4. The skin sensitisation test was performed by the Buehler method, and according to OECD Test Guideline 406. 20 Guinea pigs (Bor. DHPW (SPF)) were treated dermally with NC-4 in olive oil at a dose level of 2000 mg/kg. Two induction exposures were conducted, followed by a single challenge exposure. A concurrent control group was exposed to untreated vehicle during the induction phase.
No animals showed signs of sensitisation following the challenge exposure.
Migrated from Short description of key information:
Skin sensitisation, guinea pigs (Buehler test) - not sensitising (0 positive responses out of 20 guinea pigs tested).
Justification for classification or non-classification
In a skin sensitisation test conducted in guinea pigs, no animals (out of 20 tested) were found to exhibit signs of sensitisation. On this basis, it is concluded that NC-4 does not meet the criteria for classification as a skin sensitiser.
No data was available regarding respiratory information for NC-4.
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