Registration Dossier
Registration Dossier
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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Pseudokirchneriella subcapitata, 72-hour EC50 < 18.5 µg/L, NOEC = 18.5 µg/L.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 18.5 µg/L
Additional information
An algal inhibition test (Huntingdon Life Sciences, 2011) was conducted to determine the 72 -hour EC50 of NC-4. The study was performed according to OECD test guideline 201 and EC test guideline C3, and in compliance with GLP. Following a range-finding test, a definitive limit test was conducted at nominally 50 µg/L, which was intentionally greater than the stated water solubility of 43.8 µg/L.
No inhibition of the test group was seen relative to the solvent control group, and no morphological abnormalities were seen in the algal cells. The mean measured concentration of NC-4 in the algal medium throughout the definitive test was found to be 18.5 µg/L On the basis that no reduction in final cell count, and no inhibition in growth rate was seen in the test group compared to the solvent control, it is concluded that the 72 -hour EC50 for NC-4 is greater than 18.5 µg/L, and the No Observed Effect Concentration (NOEC) is 18.5µg/L.
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