Dodecaaluminium trimolybdenum dodecaoxide

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09 Nov - 23 Nov 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

(adopted Feb 1987)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Version / remarks:

(adopted May 2008)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Secrétariat général du GIPC-DGCIS, Service de l'industrie bureau de la chimie, 12, rue Villot, 75572 Paris cedex 12

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dodecaaluminium trimolybdenum dodecaoxide

EC Number:

239-183-9

EC Name:

Dodecaaluminium trimolybdenum dodecaoxide

Cas Number:

15123-80-5

Molecular formula:

Al2Mo3O12

IUPAC Name:

dialuminium(3+) tris(dioxomolybdenumbis(olate))

Details on test material:

- Name of test material (as cited in study report): Aluminium molybdate
- Physical state/appearance: white powder
- Analytical purity: > 99%
- Batch No.: GRA 2011-10-13-01
- Storage: room temperature
- Expiry date: Nov 2018

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Elevage Janvier (53940 Le Genest St Isle, France)
- Age at study initiation: (males) 7 weeks; (females) 8 weeks
- Weight at study initiation: (males) 236 - 246 g; (females) 210 - 220 g
- Housing: groups of 5 in solid-bottomed clear polycarbonoate cages with a stainless steel mesh lid
- Diet: M20, SDS; ad libitum
- Water: tap water; ad libitum (microbiological and chemical analyses of the water were carried out every six months)
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

paraffin oil

Details on dermal exposure:

TEST SITE
- Area of exposure: dorsal area of the trunk (clipped 24 h before application)
- % coverage: at least 10%
- Type of wrap if used: porous gauze dressing

REMOVAL OF TEST SUBSTANCE
- Washing: yes (with liquid paraffin)
- Time after start of exposure: 24 h

TEST MATERIAL
- Concentration: 200 mg/mL
- Constant volume or concentration used: yes
- For solids, paste formed: yes

VEHICLE
- Amount applied (volume or weight with unit): 10mL/kg
- Concentration: 200 mg test substance per mL vehicle

Duration of exposure:

24 h

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

other: Yes; in a current control study (TAD-2011-008), 10 rats were treated with liquid paraffin under the same conditions.

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: on day 0, 2, 7, and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, body weight gain

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: limit test; no effects

Mortality:

No mortality occurred.

Clinical signs:

other: No clinical signs of toxicity were observed.

Gross pathology:

No abnormalities were detected.

Other findings:

No local reactions were observed.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU