Dodecaaluminium trimolybdenum dodecaoxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08 Nov - 23 Nov 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Version / remarks:

(adopted Dec 2001)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)

Version / remarks:

(No. 440/2008)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Secrétariat général du GIPC-DGCIS, Service de l'industrie bureau de la chimie, 12, rue Villot, 75572 Paris cedex 12

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dodecaaluminium trimolybdenum dodecaoxide

EC Number:

239-183-9

EC Name:

Dodecaaluminium trimolybdenum dodecaoxide

Cas Number:

15123-80-5

Molecular formula:

Al2Mo3O12

IUPAC Name:

dialuminium(3+) tris(dioxomolybdenumbis(olate))

Details on test material:

- Name of test material (as cited in study report): Aluminium molybdate
- Physical state/appearance: white powder
- Analytical purity: > 99%
- Lot/batch No.: GRA 2011-10-13-01
- Expiration date of the lot/batch: Nov 2018
- Storage: room temperature

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Elevage Janvier (53940 Le Genest St Isle, France)
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: 187 - 230 g
- Fasting period before study: yes
- Housing: groups of 3 in solid-bottomed clear polycarbonate cages with a stainless steel mesh lid
- Diet: M20, SDS; ad libitum
- Water: tap water; ad libitum (microbiological and chemical analyses were carried out once every six months)
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr): approx. 15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 2 g test substance in 10 mL vehicle
- Amount of vehicle (if gavage): 10 mL/kg

MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg

DOSAGE PREPARATION (if unusual): The preparation was magnetically stirred to obtain a yellow homogeneous suspension just before administration.

CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: limit test

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

6 (2 groups of 3 females; consecutive treatment)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: day 0, 2, 7, and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, body weight gain

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: limit test; no effects (The LD50 cut-off may be considered to be 5000 mg/kg bw by oral route in rats according to OECD TG 423.)

Mortality:

No mortality occurred.

Clinical signs:

other: No clinical signs of toxicity were observed.

Gross pathology:

No abnormalities were detected.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU