Registration Dossier
Registration Dossier
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EC number: 210-647-2 | CAS number: 620-67-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC ≥ 40.7 mg/L for activated sludge microorganisms (BODIS Test)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) to aquatic microorganisms are available. According to Regulation (EC) No. 1907/2006, Annex VIII, 9.1.4, column 2, this type of study does not need to be conducted if there are mitigating factors indicating that microbial toxicity is unlikely to occur, for instance if the substance is highly insoluble in water. Propane-1,2,3-triyl trisheptanoate has a water solubility < 0.05 mg/L. The Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2008) states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms.
Nevertheless, if such a contact takes place, the ready biodegradability test conducted for this substance (Scholz, 1999) showed that nearly complete biodegradation (92%) occurred after an exposure of 28 days to propane-1,2,3-triyl trisheptanoate. According to the Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2008), the assumption that the substance is not inhibitory to the microorganisms is implicit in ready biodegradability tests. If a substance shows good biodegradation in such a test, the tested concentration can be used as a NOEC value (in the case of propane-1,2,3-triyl trisheptanoate, NOEC ≥ 40.7 mg/L).
Since no toxicity to aquatic microorganisms has been observed either in any other Glyceride category member, and considering the information above, it can be concluded that propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) will not exhibit toxicity to aquatic microorganisms.
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