Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 92/69/EWG, B.3; OECD 402 (1987)
GLP compliance:
yes
Limit test:
no

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
water
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 400 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Clinical signs: piloerection, pallor, decreased motility,
abdominal position, narrowed palpebral fissure and laboured
breathing (2000, 400 mg/kg).
Gross pathology:
Effects on organs:
2000 mg/kg bw:

Females which died:

partial induration, black discoloration of the skin at the
treatment area, spotted liver.

Sacrificed males:

partial induration, skin detachment and brownish-black
discoloration of the skin.


400 mg/kg; females:

partial induration, skin detachment, brownish-red
discoloration of the skin, partly ecrustation.
Other findings:
Signs of toxicity (local):
Partial induration, encrustation and formation of scale,
partial detachment of the skin and black / red-brown
discolourations at the site of treatment (2000, 400 mg/kg).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU