Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: 96/54/EG, B.1tris (Akute-toxische-Klassen-Methode); OECD 423 (2001)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Vehicle:
water

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 300 mg/kg bw
Mortality:
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
2000 mg/kg:

Decreased motility, uncoordinated gait, piloerection,
labored breathing, abdominal position and narrowed

palpebral fissure.


300 mg/kg:

Decreased motility, uncoordinated gait, piloerection,
labored breathing, abdominal position and narrowed palpebral
fissure, observed 30 minutes - 2 days after treatment.
Gross pathology:
Effects on organs:
2000 mg/kg:

Spotted, clay-coloured liver, hemorrhagic stomach, spotted,
black spleen and spotted and hemorrhagic kidneys.


300 mg/kg:

No findings.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU