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Diss Factsheets
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EC number: 208-778-5 | CAS number: 541-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Results of the study are not described in detail. The numbers of rats in each group is only 8. Concentrations of test material were not confirmed analytically.
Data source
Reference
- Reference Type:
- publication
- Title:
- The subacute inhalation toxicity of 109 industrial chemicals.
- Author:
- Gage JC.
- Year:
- 1 970
- Bibliographic source:
- Brit J Indust Med 27:1-18
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Deviations:
- no
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl chloroformate
- EC Number:
- 208-778-5
- EC Name:
- Ethyl chloroformate
- Cas Number:
- 541-41-3
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- ethyl chlorocarbonate
- Details on test material:
- - Name of test material (as cited): ethyl chloroformate
- Physical state: liquid
- Other: boiling point 95°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley park
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Alderley Park
- Weight at study initiation: 200 g
- Diet (e.g. ad libitum): withheld during exposure
- Water (e.g. ad libitum): withheld during exposure
ENVIRONMENTAL CONDITIONS
No data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Remarks on MMAD:
- MMAD / GSD: vapor, therefore not applicable
- Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- Generation of the test atmosphere: The exposure chamber was not described in detail. Air used for the atmospheres was filtered, dried to a relative humidity of less than 10%, and supplied at a line pressure of 1 atm. Test material was dissolved in petroleum ether and injected into a metered stream of air with a controlled fluid-feed atomizer. The concentrations tested were calculated from the rate of introduction of test material into the air stream. They were not verified analytically.
- Duration of treatment / exposure:
- 6 h / day
- Frequency of treatment:
- 5 days/week for 2-4 weeks
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1, 5, 20 ppm
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
4.5; 22.6; 90.2 mg/m³
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- no data
- Positive control:
- not necessary
Examinations
- Observations and examinations performed and frequency:
- Rats were weighed each morning and their conditions and behavior were recorded throughout the exposure period. They were allowed free access to food and water at all times except for during exposure. Urine was collected overnight after the last exposure day. On the following day, the rats were euthanized and blood was collected via cardiac puncture. Urine was analyzed for specific gravity, pH, reducing sugars, bilirubin and protein. Blood was analyzed for hemoglobin concentration, packed cell volume, mean corpuscular hemoglobin content, white cell count (total and differential), platelet count, clotting function, and the concentrations of urea, sodium and potassium. The results of these analyses were compared to those from blood collected before exposure.
- Sacrifice and pathology:
- After a gross examination of the organs, the lungs were inflated with fixative and examined histologically. The liver, kidneys, spleen and adrenals (and occasionally the heart, jejunum, ileum and thymus) were also fixed and examined histologically.
- Statistics:
- none
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- There were no signs of toxicity in rats exposed to 1 ppm. Rats exposed to 5 ppm had reduced weight gains and normal appearing organs at necropsy. Rats exposed to 20 ppm exhibited nasal irritation, difficulty with respiration, poor condition and weight loss. Autopsies revealed distension and
hemorrhage of lungs.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 1 ppm
- Sex:
- male/female
- Basis for effect level:
- other: body weight
- Dose descriptor:
- LOAEC
- Effect level:
- 5 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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