Registration Dossier
Registration Dossier
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EC number: 201-758-7 | CAS number: 87-62-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
2,6-DMA is a carcinogen in rats causing invasive tumours of the nasal cavity. These tumours develop in tissues which show inflammatory processes at the same time and prior to the occurrence of tumours. It remains open whether inflammatory and toxic effects play a rote in tumour development. However, 2,6-DMA is N-oxidised to genotoxic products, binds to DNA at the target tissue, and forms a type of DNA-adduct analogue to that observed with genotoxic carcinogenic polycyclic arylamines.Hence, the mode of action of nasal tumour development in experimental animals remains open. Under these conditions, no health-based DNEL/DMEL can be derived.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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