Registration Dossier
Registration Dossier
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EC number: 204-614-1 | CAS number: 123-28-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
not relevant
Key value for chemical safety assessment
Additional information
In accordance with column 2, paragraph 9.3.2 of REACh Annex IX, a bioaccumulation study in aquatic species does not need to be conducted if the substance has a low bioaccumulation potential and/or a low potential to cross biological membranes or direct or indirect exposure of the aquatic compartment is unlikely. The substance is regarded as readily biodegradable and therefore exposure to the aquatic compartment is unlikely.
Furthermore, three different QSAR calculations have been performed to show that the substance is not bioaccumulative.
1. Catalogic: BCF = 7.43 (all mitigating factors applied)
2. T.E.S.T.: BCF = 5.79
3. EPISuite: BCF = 15.2
Neither of the QSAR calculations revealed a significant potential for bioaccumulation.
Additionally, according to ECHA's Guidance on information requirements and chemical safety assessment R.11 PBT assessment, substances with a DiamMax-average greater than 1.7 nm plus a molecular weight of greater than 1100 are unlikely to have a BCF > 2000. The compound has a DiamMax-average of 3.01 nm which is regarded as a clear indication that the substance does not accumulate to a significant amount.
In conclusion, due to the results from the biodegradation studies, the exposure of the aquatic compartment is unlikely. Furthermore, different QSAR calculations do not reveal any potential to bioaccumulate which is supported by the molecular size of the compound which limits passing of biological membranes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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