Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-614-1 | CAS number: 123-28-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects occur within the range of solubility
Key value for chemical safety assessment
Additional information
The study was performed according to OECD guideline no. 203 (1984). The nominal concentrations were 10, 18, 32, 58 and 100 mg/L (measured concentrations: 5.15, 11.3, 18.5, 46.3, 71.3 mg/L, respectively). The LC0 and the LC50 (96h) in Danio rerio are both higher than 71 mg/L, according to the measured concentrations at the beginning and at the end of the study (average of the two values). The test compound concentration did not change during the test period. The substance was mixed with alkylphenol-polyglycoether and tetrahydrofuran to make a stock solution (1 and 132 mg/L, respectively). The test substance was present at least partially as a suspension.
No mortality was observed.
In a non-GLP guideline study according to OECD 203 and performed with a structural analogue, no toxic effects were observed up to the highest test concentration = 100 mg/L in Danio rerio. Though some deviations from the guideline were employed (e.g. the test substance and vehicle were added directly to the water in the tanks, very high vehicle concentration) the test is considered to be valid. Therefore, no toxic effects occur at the range of solubility.
Both effect concentrations are well above the solubility limit of the test substances (water solubility < 1 mg/L, see chapter 4.8 in IUCLID). Therefore, they represent a worst case assumption where water solubility is achieved by excessive use of solvent. In conclusion, the substance shows no effect in the range of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
