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EC number: 203-813-0 | CAS number: 110-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Version / remarks:
- July 1989
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Piperidine
- Physical state: Liquid, Colorless
- Analytical purity: no data
- Lot/batch No.: 20221AA
- Storage condition of test material: Room Temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Wilmington, MA
- Age at study initiation: 49 to 74 days
- Weight at study initiation: 200 and 300 g
- Fasting period before study: overnight
- Housing: polycarbonate cages
- Diet: rodent ration (AgWay Prolab, Waverly, NY), ad libitum
- Water: tap water, ad libitum
- Acclimation period: 7 days (Range finding), four days (LD50)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 30-70
- Air changes (per hr): 10 to 13
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- USP
- Details on oral exposure:
- DOSAGE PREPARATION: Each dose preparation was placed on a magnetic stir plate and stirred for 10 minutes prior to dosing to ensure a homogenous solution
- Doses:
- Range Finding Trial: 2000, 1200, 800, 300, and 100 mg/kg
LD50 Trial: 300, 550 and 800 mg/kg - No. of animals per sex per dose:
- in the range finding study one male, one female;
in the main study 5 animals per sex. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: day 0 (day of dosing), 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- The LD50 was determined by the method of Linear Regression using the program "Linear Regression I" by R.J. Tallarida and R.B. Murray, (Manual of Pharmacologic Calculations with Computer Programs, Springer Verlag, New York, 1986, pp 10-13).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 740 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 800 mg/kg: 1/5 males and 2/5 females died within 4 hours; 2/5 males died within one day and 2/5 females died within 6 days; in total 7/10 animals died.
550 mg/kg = 0/10
300 mg/kg = 0/10 - Clinical signs:
- other: 800 mg/kg: rats showed the following clinical signs during the observation period: catalepsy, tremors and lethargy. One surviving male appeared emaciated from day 7 to day 10. 550 mg/kg: clinical signs observed in rats included somnolence, catalepsy, let
- Gross pathology:
- 800 mg/kg: Gross necropsy findings in rats of this dose group included haemorrhaging in the stomach and small intestines; adhesion of the stomach, small intestine and spleen to the abdominal cavity wall; brownish fluid in the abdominal cavity and discoloration of the kidneys.
550 mg/kg: Gross necropsy findings in rats of this dose group included adhesion of the stomach and spleen and thickening of the forestomach mucosa.
300 mg/kg: no signs of toxicity were observed at gross necropsy. - Other findings:
- Range Finding:
Body Weights: All of the surviving animals gained body weight
Clinical Observations: The surviving animals did not show any clinical signs during the observation period.
Mortality: All animals of the dose groups 2000, 1200 and 800 mg/kg (one male and one female each) died within 4 hours after treatment. The animals in the two lowest dose group levels (300 and 100 mg/kg body weight) survived the entire observation period.
Necropsy: Animals that died during the study revealed signs of toxicity that included haemorrhaging in the stomach and the small and large intestine. No unusual lesions were noted in any of the surviving animals.
Based on the results of the Range Finding Study, the doses for the the LD50 determination study were selected to be 800, 550, and 300 mg/kg.
Any other information on results incl. tables
Table1 Acute oral toxicity.
Dose [mg/kg bw] |
Mortality |
Clinical signs |
|||
|
N* |
% |
Time of death |
N* |
Duration |
Males |
|
|
|
|
|
800 |
3/5 |
60 |
4h / day 1 |
4/5 |
- |
550 |
0/5 |
0 |
- |
5/5 |
- |
300 |
0/5 |
0 |
- |
0/5 |
- |
Females |
|
|
|
|
|
800 |
4/5 |
80 |
4 h / day 6 |
3/5 |
- |
550 |
0/5 |
0 |
- |
5/5 |
- |
300 |
0/5 |
0 |
- |
0/5 |
- |
*N= Number of animals/ number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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