Registration Dossier
Registration Dossier
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EC number: 203-813-0 | CAS number: 110-89-4
Neurotoxicity
Administrative data
Description of key information
Repeated dose, inhalative, rat, GLP, OECD Guideline 412: systemic NOAEC males and females: 350 mg/m³ (BASF 46I0523/89065, 1993).
Key value for chemical safety assessment
Additional information
The neurotoxicity of the test item was investigated in a 28 -day inhalation study in rats performed according to OECD guideline 412 using a functional observational battery of 32 parameters of sensory and motor function and neurohistopathological examination after perfusion fixation (see Chapter 7.5.2, key.BASFAG46I0523/89065.1993.Repeated dose toxicity: inhalation, rat, 28 days). Concentration levels up to 100 ppm (350 mg/m³) with whole-body exposure for 6 hours per day and 5 days per week showed no neurotoxic effects.
Bazarova (1973, IUCLID Chapter 7.5.2) reported that repeated exposure of rats to concentrations 2 or 10 mg/m³ (0.58 and 2.9 ppm) for 4 months caused multiple effects in rats including neurotoxicity. Details were insufficient for an adequate assessment.
Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data for neurotoxicity are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. As a result, the substance is not warranted to be classified for neurotoxicity, under Regulation (EC) No.1272/2008.
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