2-ethylhexyl mercaptoacetate

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: Clinical observation data

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Study suffering severe limitations as not sufficiently described.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1972

Materials and methods

Study type:

clinical case study

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Clinical observation of workers exposed to thioglycolic acid 2-ethylhexyl ester were reported.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl mercaptoacetate

EC Number:

231-626-4

EC Name:

2-ethylhexyl mercaptoacetate

Cas Number:

7659-86-1

Molecular formula:

C10H20O2S

IUPAC Name:

2-ethylhexyl 2-sulfanylacetate

Details on test material:

- Name of test material (as cited in study report): Thioglykolsäureisoctylester (TGSE)

Method

Subjects:

No precise description of the 2 populations concerned:
- Workers involved in the manufacture of thioglycolic acid 2-ethylhexyl ester;
- Laboratory workers involved in the study of the effects of thioglycolic acid 2-ethylhexyl ester on the blood pressure of rabbits and dogs (See Hollenbach et al. (1972)/Specific investigations Blood pressure 01) esposed to the substance for several days.

Route of exposure:

other: no data

Reason of exposure:

intentional, occupational

Exposure assessment:

not specified

Results and discussion

Clinical signs:

- Workers involved in the manufacture of thioglycolic acid 2-ethylhexyl ester frequently complained of headaches, dizziness, tiring, general weariness and gastrointestinal symptoms. Circulatory stimulants alleviated the syndrome for a short time in some cases, so that the cause was assumed to be a hypotensive effect.

- Laboratory workers involved in the study of the effects of thioglycolic acid 2-ethylhexyl ester on the blood pressure of rabbits and dogs complained of symptoms of thy type and particularly of headaches. The laboratory workers were also in contact with thioglycolic acid and ethanol for the same period as the study period with thioglycolic acid 2-ethylhexyl ester.

Applicant's summary and conclusion

Executive summary:

As part of a study for assessing effects of exposure to 2 -EHTG on blood pressure of rabbits and dogs, clinical observations of symptoms of workers exposed to the substance were reported.

Workers involved in the manufacture of thioglycolic acid 2-ethylhexyl ester frequently complained of headaches, dizziness, fatigue, general weariness and gastrointestinal symptoms. Circulatory stimulants alleviated the syndrome for a short time  in some cases, so that the cause was assumed to be a hypotensive effect. The laboratory workers involved in the study of the effects of  thioglycolic acid 2-ethylhexyl ester on the blood pressure of rabbits and  dogs similarly complained of symptoms of this type and particularly of  headaches, after exposure to thioglycolic acid 2-ethylhexyl ester for  several days. The laboratory workers were also in contact with thioglycolic acid and ethyl hexanol (no further details provided).