2-chlorobenzonitrile

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-chlorobenzonitrile

EC Number:

212-836-5

EC Name:

2-chlorobenzonitrile

Cas Number:

873-32-5

Molecular formula:

C7H4ClN

IUPAC Name:

2-chlorobenzonitrile

impurity 1

Reference substance name:

unknown

IUPAC Name:

unknown

Test material form:

solid

Test animals

Species:

rat

Strain:

other: SPF albino

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

other: propylene glycol

Analytical verification of test atmosphere concentrations:

no

Remarks:

The highest concentration being possible in air was calculated from the results of weighings of the solution, converted to pure, undissolved sample material.

Duration of exposure:

4 h

Concentrations:

440 mg/m³ (highest concentration possible)

No. of animals per sex per dose:

five animals per sex (only one dose)

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC0

Effect level:

>= 440 mg/m³ air

Exp. duration:

4 h

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

2-Chlorobenzonitrile presents little acute inhalation hazard.

Executive summary:

The aim of this study was to determine the 4-hour acute inhalation toxicity of 2-Chlorobenzonitrile. Five male and female rats each were exposed (whole body) to the test atmosphere generated by dispersing 2-Chlorobenzonitrile in nine parts propylene glycol to a fine mist by means of an aerodynamic nozzle nebulizer. The mist was passed through a glass exposure cylinder of 15 L capacity at a rate of 1.5 m³/h. The rats were exposed to the highest concentration of 2-Chlorobenzonitrile possible, being 440 mg/m³.

Clinical signs were recorded during exposure and daily thereafter for 14 days. At termination of the study, all surviving animals were subjected to gross necropsy.

Neither mortality nor injury was observed in any of the rats. After the 14 day observation period, at autopsy macroscopical examination did not reveal any deleterious effects.

From the results of the present acute inhalation toxicity test with rats it appeared that a 4 hour exposure to a fine dispersion of 2-Chlorobenzonitrile at a concentration of 440 mg/m³ of air produced no mortality or grossly visible injury. As it is unlikely that the substance will occur at higher concentrations in practice, this results indicates that the product presents little acut inhalation hazard.