Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
other information
Study period:
2000
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Estimation based on chemical structure.
GLP compliance:
no

Test material

Radiolabelling:
no

Study design

Analytical monitoring:
no

Results and discussion

Transformation products:
no

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Executive summary:

ZK 34517 does not contain functional groups which are susceptible to hydrolytic cleavage. ZK 34517 is to be considered hydrolytically stable in the relevant pH region 4 - 9.

The test substance molecule and all of its functional groups belong to a class of

substances that are generally resistant to hydrolysis, e.g.:

alkanes, alkenes, alkynes, benzenes/biphenyls, polycyclic aromatic hydrocarbons,

heterocyclic polycyclic aromatic hydrocarbons, halogenated aromatics, aromatic nitro

compounds, aromatic amines, alcohols, phenols, glycols, ethers, aldehydes, ketones,

carboxylic acids, sulfonic acids.(Ref.: Lyman, W. J.; Reehl, W. F.; Rosenblatt, D. H.; Handbook of Chemical

Property Estimation Methods, McGraw-Hill New York 1982, p. 7-4).