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EC number: 228-846-8 | CAS number: 6362-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Start of study: 18 March 2005. End of study: 8 June 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to guideline but no GLP stated.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: At initiation and after 5 days (for each pH)
- Buffers:
- - pH: 4.0: 45.0 mL of 0.1 mol/L sodium hydroxide and 250 mL of 0.1 mol/L potassium dihydrogen citrate were filled up to a volume of 500 mL with purified water
-pH 7.0: 148.15 mL of 0.1 mol/L sodium hydroxide and 250 mL of 0.1 mol/L potassium dihydrogen phosphate were filled up to a volume of 500 mL with purified water
-pH 9.0: 106.5 mL of 0.1 mol/L sodium hydroxide and 250 mL of 0.1 mol/L potassium chloride / 0.1 mol/L boric acid were filled up to a volume of 500 mL with purified water
Each buffer solution was aerated with nitrogen gas for approximately 5 minutes, then filter sterilized with a membrane filter (0.22 μm). - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Stoppered quartz test tubes ( covered with aluminium foil)
- Lighting: Protected from light
TEST MEDIUM
-Test concentration: 0.0500 mg/L
- Volume used: 5 mL - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.05 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.05 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.05 mg/L
- Number of replicates:
- 2 (for each measurement point, but one at initiation)
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- no
- % Recovery:
- >= 94.6 - <= 98.5
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- 5 d
- % Recovery:
- >= 96.9 - <= 98
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 5 d
- % Recovery:
- >= 96.5 - <= 101
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 5 d
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Details on results:
- From the results, the residual rate of the test substance after 5 days in test solutions of pH 4.0, pH 7.0 and pH 9.0 at 50±0.1°C was 90% or more, and its half-life at 25°C is considered to be 1 year or more.
Because the water solubility of the test substance is low at 0.230 mg/L*, the concentration set for this study was 0.0500 mg/L. In the results, a decrease in concentration thought to be due to adsorption of the test substance to the test vessel was observed. When periodic sampling of test solutions was done, the residual rate at 1 hour after initiation of the hydrolysis test was less than 90% compared to initiation at 84.4-89.8% (References 1 and 2, Fig. 2).
Considering the structure of the test substance, there is no site which could be subjected to hydrolysis. Decreased sample concentrations were not observed in subsequent sampling, and a constant residual rate was obtained (References 1, 2 and 3, Fig. 2). Thus, after a certain amount of adsorption to the test vessel, the test substance is thought to be stable in test solutions of pH 4.0, pH 7.0 and pH 9.0 at 50±0.1°C.
Therefore, in the present study, sample concentrations at 1 hour after the start of hydrolysis were used as the initial concentrations to calculate the residual rate after 5 days
* Measurement of solublity of 2,4-diphenyl-4-methyl-1-pentene (see section 4.8 for details on study) - Conclusions:
- The residual analysis of 2,4-diphenyl-4-methyl-1-pentene in test solutions of pH 4.0, pH 7.0 and pH 9.0 at 50±0.1°C was 90% or more and its half life at 25°C is considered to be > 1 year.
Reference
The results of measurement were as follows:
Test solution |
Initial concentration (mg/L) |
Concentration after 5 days (mg/L) |
Residual rate (%) |
|
Measured value |
Average |
|||
pH4.0 |
0.0392 |
0.0386 |
98.5 |
96.5 |
0.0371 |
94.6 |
|||
pH7 .0 |
0.0398 |
0.0390 |
98.0 |
97.5 |
0.0386 |
96.9 |
|||
pH9.0 |
0.0391 |
0.0378 |
96.5 |
98.6 |
0.0394 |
101 |
Description of key information
The residual analysis of 2,4-diphenyl-4-methyl-1-pentene in test solutions of pH 4.0, pH 7.0 and pH 9.0 at 50±0.1°C was 90% or more and its half life at 25°C is considered to be > 1 year.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The hydrolysis as a function of pH of the test item was assessed according to OECD Guideline 111. The residual analysis of 2,4-diphenyl-4-methyl-1-pentene in test solutions of pH 4.0, pH 7.0 and pH 9.0 at 50±0.1°C was 90% or more and its half life at 25°C is considered to be > 1 year.
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