Registration Dossier
Registration Dossier
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EC number: 204-200-0 | CAS number: 117-61-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS NUMBER : DV5230000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1061,1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzidine-2,2’-disulphonic acid
- IUPAC Name:
- Benzidine-2,2’-disulphonic acid
- Reference substance name:
- 204-200-2
- IUPAC Name:
- 204-200-2
- Reference substance name:
- Benzidine-2,2'-disulphonic acid
- EC Number:
- 204-200-0
- EC Name:
- Benzidine-2,2'-disulphonic acid
- Cas Number:
- 117-61-3
- Molecular formula:
- C12H12N2O6S2
- IUPAC Name:
- 4,4'-diamino-[1,1'-biphenyl]-2,2'-disulfonic acid
- Details on test material:
- - Name of test material: Benzidine-2,2’-disulphonic acid
- Molecular formula: C12H12N2O6S2
- Molecular weight: 344.369
- Substance type: organic
- Physical state: solid
Constituent 1
Constituent 2
Constituent 3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24H
Results and discussion
In vivo
Results
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: mild irritating
Applicant's summary and conclusion
- Interpretation of results:
- other: mild irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The substance Benzidine-2,2’-disulphonic acid was found to be mild irritating to the eyes of rabbit at dose concentration of 500mg/24 hrs.
- Executive summary:
The substance Benzidine-2,2’-disulphonic acid was found to be mild irritating to the eyes of rabbit at dose concentration of 500mg/24 hrs.
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