Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The aquatic toxicity was studied in fish (Oryzias latipes). Fish were exposed to several concentrations of indometacin over 96 hours. The LC50 was determined with 81.9 mg/L. (Kim JW, Ishibashi H, Yamauchi R, Ichikawa N, Takao Y, Hirano M, Koga M, Arizono

Acute toxicity of pharmaceutical and personal care products on freshwater crustacean

(Thamnocephalus platyurus) and fish (Oryzias latipes). J Toxicol Sci 34 (2), 227 -232, 2009.)

The aquatic toxicity was studied in the non-standard freshwater crustacean Thamnocephalus platyurus. The crustaceans were exposed to several concentrations of indometacin over a period of 24 hours. The EC50 was determined with 16.1 mg/L.

(Kim JW, Ishibashi H, Yamauchi R, Ichikawa N, Takao Y, Hirano M, Koga M, Arizono

Acute toxicity of pharmaceutical and personal care products on freshwater crustacean

(Thamnocephalus platyurus) and fish (Oryzias latipes). J Toxicol Sci 34 (2), 227 -232, 2009.)