Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-186-5 | CAS number: 53-86-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 986
- Bibliographic source:
- Yakuri to Chiryo. Pharmacology and Therapeutics, 14 : 3185-3198 ( as cited in RTECS)
Materials and methods
Test material
- Reference substance name:
- Indometacin
- EC Number:
- 200-186-5
- EC Name:
- Indometacin
- Cas Number:
- 53-86-1
- Molecular formula:
- C19H16ClNO4
- IUPAC Name:
- 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Species (Strain) |
Route of Administration (Vehicle) |
Gender |
LD50 (mg/kg bw) |
Remarks |
Reference |
|
Rat |
Dermal |
n.s. |
> 250 (lethal dose) |
|
Yakuri to Chiryo. Pharmacology and Therapeutics. 14, 3185, 1986 |
|
Guinea pig |
Dermal |
n.s. |
> 100 (lethal dose) |
excitement |
Yakuri to Chiryo. Pharmacology and Therapeutics. 14, 3185, 1986 |
|
n.s. : not specified; |
||||||
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
