Methyl phenyl sulphide

Endpoint summary

Description of key information

One key study on acute oral toxicity is available.  The study was conducted using female Wistar rats and was conducted according to the Acute Toxic Class Method (OECD Guideline 423).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

300 mg/kg bw

Additional information

Acute Oral Toxicity:

In a study conducted by Beerens-Heijnen (2010), the test substance was, Thioanisole, was administered to female Wistar rats by oral gavage in a single exposure to assess its ability to cause toxicity. The test was conducted according to the Acute Toxic Class Method, with doses of 300 and 2000 mg/kg bw used. Three female rats per dose group were used. All animals were subjected to daily observations, up to Day 15 of testing, and weekly determination of body weight, measured on Days 1, 8 and 15. Macroscopic examination was also performed on all animals. All three females at 2000mg/kg bw were found dead or sacrificed in moribund condition on Day 2. One female at 300mg/kg bw was found dead or sacrificed in moribund condition on Day 2. Body weight loss was noted in 2 females at 300mg/kg bw between Days 1 and 8. Body weight gain shown by the other surviving animals at this dose group was considered to be similar to that expected for normal untreated animals of the same age and strain. One animal showed dark red discolouration of the lungs and one showed pale discolouration of the liver at 2000mg/kg bw. At 300 mg/kg bw, no macroscopic findings observed in the surviving animals. One animal sacrificed for ethical reasons showed pale discolouration and accentuated lobular pattern in the liver.

Under the conditions of this study, the LD₅₀was determined to be in the range of 300 to 2000 mg/kg bw. Based on this result, the test substance should be classified as a Category 4 toxicant and have the signal word "Warning" and the risk phrase H302: Harmful if swallowed associated with it, in accordance with Regulation EC No. 1272/2008. According to Directive 67/548/EEC, the test substance should be have the risk phrase, R22: Harmful if swallowed.

Justification for classification or non-classification

Acute Oral Toxicity:

Based on the result of the key study, the test substance should be classified as a Category 4 toxicant and have the signal word "Warning" and the risk phrase H302: Harmful if swallowed associated with it, in accordance with Regulation EC No. 1272/2008. According to Directive 67/548/EEC, the test substance should be have the risk phrase, R22: Harmful if swallowed.