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Diss Factsheets
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EC number: 203-139-7 | CAS number: 103-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Chapman and Hall
- Year:
- 1 959
- Bibliographic source:
- Williams, R. T. Detoxication Mechanisms 1959, Chapman and Hall, London, UK.
- Reference Type:
- review article or handbook
- Title:
- DOSE Doc. no.: P73
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE);Williams, R. T. Detoxication Mechanisms 1959, Chapman and Hall, London, UK.
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number : 112
- Author:
- HSDB database
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:-Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982; p.2525
- Reference Type:
- other: Authoritative data base
- Title:
- GCID : 11048
- Author:
- ACToR database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource):-[Clayton, G. D. and F. E. Clayton (eds.). Pattys Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2525]**PEER REVIEWED**
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is taken from DOSE handbook and HSDB, ACToR database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenetole
- EC Number:
- 203-139-7
- EC Name:
- Phenetole
- Cas Number:
- 103-73-1
- Molecular formula:
- C8H10O
- IUPAC Name:
- ethoxybenzene
- Details on test material:
- - Name of test material (as cited in study report): Phenetole
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: no data
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- metabolism
- Results:
- Hydroxylated in the para position
- Type:
- excretion
- Results:
- excreted as glucuronide and ethereal sulfate
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Phenetole, like Anisole, is hydroxylated in para position & excreted as glucuronide & ethereal sulfate
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- glucuronide and ethereal sulfate
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Phenetole is hydroxylated in its para position & excreted as metabolites glucuronide & ethereal sulfate. Also, the bio-accumulation potential of the chemical varied from 21 to 48 (very low value that does not suggest bio-accumulation). Thus, considering these facts, the bio-accumulation potential of phenetole appears to be low. - Executive summary:
Phenetole is hydroxylated in its para position & excreted as metabolites glucuronide & ethereal sulfate. Also, the bio-accumulation potential of the chemical varied from 21 to 48 (very low value that does not suggest bio-accumulation). Thus, considering these facts, the bio-accumulation potential of phenetole appears to be low.
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