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EC number: 203-139-7 | CAS number: 103-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
Based on predicted data of target substance and studies of readacross reviewed for short term toxicity to fish from reliable sources having Klimisch rating 2 and 4 considering weight of evidence approach. The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1. |
LC50 |
103.4304 mg/l |
mortality
|
96 hrs.
|
Lepomis macrochirus
|
Predicted data |
2. |
LC50 |
100.5091mg/l
|
mortality
|
96 hrs.
|
Pimephales promelas
|
Predicted data |
3. |
LC 50 |
32.95 mg/l |
mortality |
96 hrs. |
Pimephales promelas |
DEPA |
3. |
LC50 |
120 mg/l
|
mortality |
48 hrs |
Leuciscus idus melanotus
|
Publication(RA-100-66-3) |
4. |
LC50 |
344 mg/l |
mortality |
96 hrs |
Pimephales promelas |
Publication(RA-122-99-6) |
5. |
LC50 |
165 mg/l 135 mg/l |
mortality |
24 hrs 48 hrs |
Ptychocheilus oregonensis |
Publication(RA-122-99-6) |
By applying weight of evidence approach the endpoint values varies between 100.5 to 344 mg/l in a 24 to 96 hrs.study on the basis of mortality effect.The LC 50 value 32.95 mg/L is a classifying value.However the data is insufficient for classifying the substance. Thus, considering the CLP Criteria for aquatic classification of the substance and weight of evidence approach , it is concluded that Phenetole does not exhibit short term toxicity to fish (Lepomis macrochirus, Pimephales promelas, Leuciscus idus melanotus & Ptychocheilus oregonensis).
Long-term toxicity to fish
According to column I of annex IX, Long-term toxicity testing on fish was considered for waiver as short term toxicity data has already been provided as part of Annex VIII requirements.
Short-term toxicity to aquatic invertebrates
Based on predicted data of target substance(K2) and studies of readacross reviewed for short term toxicity toaquatic invertebrate from reliable sources having Klimisch rating 4 considering weight of evidence approach. The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1. |
EC50 |
117.0316 mg/L |
Intoxication |
48 hrs |
Daphnia magna |
Predicted data |
2. |
LC50 |
488 mg/L |
Mortality |
48 hrs |
Daphnia magna |
Study report(RA-122-99-6) |
3. |
LC50 |
2.7 mg/L |
Mortality |
48 hrs |
Daphnia magna |
DEPA |
By applying weight of evidence approach the endpoint values for target was assessed as follows- EC50-117.0316 mg/L,LC 50 value of target was predicted to be 2.7 mg/l. However the data was insufficient to classify the substance in aquatic chronic category. Thus considering the weight of evidence approach for target and readacross values it was concluded that phenetole does not exhibit toxicity toaquatic invertebrate.
Long-term toxicity to aquatic invertebrates
According to column 1 of Annex IX;Long-term toxicity testing on invertebrate was considered for waiver since the information on acute toxicity has already been provided as a part of Annex VII requirements.
Toxicity to aquatic algae and cyanobacteria
Based on studies reviewed for toxicity to aquatic algae and cyanobacteria from reliable sources having Klimish rating 2and 4 for target and readacross.
The summary of the results are presented below
Sr.no |
Endpoint |
Effect values |
Basis for effects |
duration |
species |
Remarks |
1 |
EC50 |
162mg/l |
Growth |
96 hrs. |
Pseudokirchnerella subcapitata |
Publication RA 100 -66 -3 |
2 |
NOEC |
3.211644 mg/l |
Growth |
72 hrs. |
Pseudokirchnerella subcapitata |
Predicted data |
3 |
LOEC |
21.7231 mg/l |
Population |
120 hrs. |
Pseudokirchnerella subcapitata |
Predicted data |
By applying weight of evidence approach the endpoint values was found to be EC50=162mg/l;NOEC=3.211644mg/l and LOEC=21.7231 mg/l in a 72 to 120 hrs.study on the basis of growth and population effect.Thus,considering the CLP Criteria for aquatic classification of the substance , it is concluded that Phenetole does not exhibit toxicity to aquatic algae and cyanobacteria(Pseudokirchnerella subcapitata).
Toxicity to microorganisms
Based on the various studies reviewed for target substance phenetole for the endpoint toxicity to microorganism with Klimisch rating 2 and 4.The results are summarized as follows-
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1. |
EC50 |
7.3 mg/L |
Growth inhibition |
30 min |
Photobacterium phosphoreum |
Publication |
2. |
IGC50 |
169 mg/L |
Growth inhibition |
48 hrs |
Tetrahymena pyriformis |
Publication |
3. |
pT |
5.33 mg/L |
Physiology |
4.98 min |
Vibrio fisheri |
Publication |
Based on the above values the inhibition concentration varies from 5.33 -169 mg/L.Also the EC50 value was assessed to be7.3 mg/L.
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