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Physical & Chemical properties

Storage stability and reactivity towards container material

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The study (Wyeth, 1991) was divided into pyrex container and amder glass ampules.
In pyrex vessels, the only degradation product detected at pH 1 was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene.
In the amber glass ampules, a total of eight degradation products were detected - seven of which were identified. At low pH (1-4), the major degradation product was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene. At high pH (8-10), the major degradation product was 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol. From pH 5-7, the major degradation product observed was 3-methoxybenzaldehyde. However, the reaction rate was extremely slow in the pH range of 5-7.

Additional information

The study (Wyeth, 1991) was divided into pyrex container and amder glass ampules.

In pyrex vessels, the only degradation product detected at pH 1 was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene.

In the amber glass ampules, a total of eight degradation products were detected - seven of which were identified. At low pH (1-4), the major degradation product was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene. At high pH (8-10), the major degradation product was 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol. From pH 5-7, the major degradation product observed was 3-methoxybenzaldehyde. However, the reaction rate was extremely slow in the pH range of 5-7.