Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Publication in Russian, a short summary was available in english. The study seems to be well described, and 2 species were tested. This data is cited in DOSE, Sax's.

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Khalepo
Year:
1968
Bibliographic source:
Toksikol. Nov. Prom. Khim. Veshchestv, 10, p : 131-140

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
no
Test type:
other: inhalation study, no more data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
other: rat and mouse
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 220 +/- 40 g

ENVIRONMENTAL CONDITIONS: 
- Temperature (°C): 28°C

No more data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
No more data
Statistics:
according to Litchfield & Wilcoxon, corrected by Pot

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
0.44 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: (0.40-0.49 mg/L) for rats
Sex:
male/female
Dose descriptor:
LC50
Effect level:
0.69 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: (0.60-0.79 mg/L) for mice

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP classification: Toxicity Category III
Executive summary:

In an acute inhalation toxicity study (Khalepo, 1968), groups of rats and mice were exposed by inhalation route to meta-trifluoromethylaniline for 4 hours. Animals were observed for 2 weeks. LC50= 0.44 mg/L for rats and 0.69 mg/L for mice.

Meta-trifluoromethylaniline is classified as toxic T R23 by inhalation route, according to the EU classification criteria (67/548/EC directive).

It is classified acute category 3 (H331), according to CLP criteria.